before the treatment


Inclusion Criteria
Acceptable criteria for treatment:

  • Age 16 – 70 years old
  • Absence of severe chronic infections
  • Negative serology HBV, HCV, HIV
  • Absence of mental and cognitive deficits and ability to provide informed consent
  • Absence of gross cognitive disturbances
  • Absence of severe concomitant diseases

Systemic autoimmune diseases:

  • Diagnosed Multiple Sclerosis with EDSS between 1.5 and 6.5 (documented progression/relapses over the previous year, with or without gadolinium-enhancing lesions).
  • Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
  • Severe systemic vasculitis
  • Systemic lupus erythematosus
  • Systemic sclerosis
  • Crohn's disease
  • Other severe systemic autoimmune conditions, including connective tissue diseases

Adequate organ function:

  • Cardiac LV Ejection Fraction >45%
  • Total Lung capacity > 60%
  • Pulmonary artery pressure < 45 mmHg
  • DLCO/VA>50%
Exclusion Criteria

List of contraindications for treatment
  • A positive test for HIV, Hepatitis B and Hepatitis C.
  • Severe extensive or prolonged infection caused by viruses, fungi and bacteria.
  • Uncontrolled diabetes.
  • Evidence myelodysplasia or other non-autoimmune cytopenia.
  • Having received a cytotoxic agent within one month prior to AHSCT.
  • Pregnancy or at risk of pregnancy, including those unwilling to practice active contraception during the time of therapy.
  • Psychiatric illness, mental deficiency, or gross cognitive dysfunction.
  • Inability to give written and informed consent in accordance with world ethics guidelines for medical treatment.
  • High disability level of MS patient

Any condition, obstructing the normal functioning of the main organs

(Heart, Kidneys, Lung, Liver etc.)
- As this would limit your ability to receive high-dose immunosuppressive therapy
with Autologous Hematopoietic Stem Cell Transplantation.